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Most prominent among these were promoters affecting genes involved in cell adhesion and axon guidance.

Both pathways involve cascades of interactions among dozens or hundreds of proteins, each one encoded by a different gene.

15 is better than 40 - and I am younger (though not by much...) than she was to see a breakthrough actually unfolding.

Even without much understanding of genome regulation a type of cancer became largely cured! Although we knew before, that "the genome is not forever" (e.g.changes with epigenomics, mutations, etc.), "Genome Editing" Researchers looked at cells sampled from 308 people with pancreatic cancer, finding mutations in gene promoter regions that provide important clues about pathways perturbed in the illness and suggesting new targets for future treatments.D., formerly of Adjunct Associate Professor Michael Schatz's lab, to focus narrowly on genome segments called gene promoters.lie adjacent to, but not within, the sequences of the genes that they regulate.In this way these mutations are unlike those usually found in KRAS and p53, for example, which impair or otherwise alter the function of the proteins they encode.

While the promoter mutations were not near known pancreatic cancer genes, the team found that they affected some of the same biological pathways in cells.

The axon guidance pathway associated with promoter mutations has a less obvious but no less important role in pancreatic cancer.

"In pancreas cancer, nerves are often attracted to or get attracted to the tumor," explains Feigin, "and sometimes they grow right through the tumor.

When they did, nuclear technology emerged prompted by the fact that fission (or fusion) releases unheard amounts of energy. First, however, quantum physics had to be developed to understand and thus control the process.

Science enabled Leo Szilárd to patent the nuclear reactor for peaceful use.

(Jul 04) [Independence Day] A 27-year-old who worked for Apple as a teenager wants to make a yearly blood test to diagnose cancer — and he just got .5 million from Silicon Valley VCs to pull it off (This portrait was taken a while ago ... What really counts is not when you explain for the first time something like Fracto Gene; "Fractal Genome Grows Fractal Organisms".