She met her husband, David Arquette, who played her on-screen love interest Dwight "Dewey" Riley, while filming the first Scream film.
Both Cox and Arquette reprised their respective roles from the Scream trilogy in 2011's Scream 4. Her other films include Ace Ventura: Pet Detective with Jim Carrey (1994), The Runner (1999), 3000 Miles to Graceland (2001), and The Shrink Is In (2001).
On the Season 9 premiere episode of the American genealogy documentary show Who Do You Think You Are?, it was discovered that Cox is descended from several key players involved in the deposing and likely murder of King Edward II of England, and also a direct descendant of William the Conqueror (her 26x great-grandfather).She also starred in a three-episode arc on former Friends co-star Lisa Kudrow's online web series Web Therapy (2009).In June 2012, Cox directed and made a cameo appearance in a Lifetime television movie called Talhotblond, which premiered on the network on June 23, 2012.In 1995, she was cast in Toad the Wet Sprocket's music video, "Good Intentions". At first the most famous cast member of the new show, Cox joined fellow castmates Jennifer Aniston (Rachel Green), Lisa Kudrow (Phoebe Buffay), Matt Le Blanc (Joey Tribbiani), Matthew Perry (Chandler Bing) and David Schwimmer (Ross Geller) for what became her most famous role, lasting for 10 seasons until 2004.
According to the Guinness Book of World Records (2005), Cox (along with her female costars) became the highest-paid TV actress of all time, with her 1 million-per-episode paycheck for the final two seasons of Friends.The Louisiana Board of Examiners for Speech-Language Pathology and audiology voted at their meeting of February 16, 2007, that all disciplinary actions beginning after February 16, 2007, will be posted within thirty days of all parties signing the final order.The final Consent Agreement and Order can be obtained by clicking the link provided below. After the conclusion of Friends, Cox was producer Marc Cherry's first choice to be offered a starring role as Susan Mayer on Desperate Housewives, but Cox was unavailable due to her pregnancy and the role later went to Teri Hatcher.A few years later, Cox signed a deal with ABC Studios (formerly Touchstone Television) to star in her own series.Cox has two older sisters, Virginia and Dorothy, and an older brother, Richard, Jr.